Which is a negative effect of using human growth hormone as a performance enhancing drug?

Adverse effects may include joint pain, muscle weakness, fluid retention.

Explanation:

Growth hormone (GH) usually causes few side effects and is well tolerated as long as it is used correctly, as prescribed by the doctor. In adults, the main side effects of GH relate to the water retention that growth hormone can promote, causing swelling, joint or muscle pain, and tingling in the extremities. However, indiscriminate use can cause greater negative effects such as: joint pain, muscle weakness, fluid retention, muscle atrophy, among others.

the insertion of a penis into a vagina.

since you have not provided the options here i   am going to give you general overview about hormone.hormone are actually the part of endocrine system in our body and produced by the endocrine glands. the hormones act like a chemical messenger   within human body. once produce by the glands they   travel through the blood stream and reach at specific or target tissue and organs   which result in control of our body function. the hormones are specific in their work and work on only the targeted tissue or organ   . with the of hormone endocrine system regulate the heart rate , metabolism, our mood and   growth as well as the development and even the sleeping cycle etc. they actually are the messenger for body cell and organs .