Muchos fármacos pueden actuar a nivel del SNC modificando las concentraciones de neurotransmisores o actuando como lo hacen estos. Otros causan tolerancia o estado de adaptación del organismo al medicamento, que tras la administración repetitiva va perdiendo su eficacia y por eso hay que aumentar la dosis para conseguir el efecto buscado. El uso de sustancias como la heroína, tabaco, alcohol y barbitúricos puede causar adicción o dependencia física, la cual produce cambios fisiológicos en las células.¿Por qué crees que las personas llegan a consumir sustancias psicoactivas como heroína, cocaína?

The correct answer would be lost aquila

The investiture controversy began as a power struggle between pope gregory vii (1072–85) and henry iv, holy roman emperor (1056–1106).[2] a brief but significant struggle over investiture also occurred between henry i of england and pope paschal ii in the years 1103 to 1107, and the issue played a minor role in the struggles between church and state in france, as well.by undercutting the imperial power established by the salian emperors, the controversy led to nearly 50 years of civil war in germany, and the triumph of the great dukes and abbots. imperial power was finally re-established under the hohenstaufen dynasty. historian norman cantor:

Answer collision and mountain formation;

Can you show the map?