How does scientific investigation begin? OA
The scientist makes accurate observations and performs background research.
Ов
The scientist develops a specific hypothesis to be sure that he or she is
focusing on the proper issue.
Ос
The scientist formulates a specific question that addresses a meaningful
problem, a question which drives the investigation from start to finish.
О O
D
The scientist develops a set of clearly defined experiments, relevant to the
hypothesis, which lead to tangible or concrete results that address the
hypothesis.

The scientist formulates a specific question that adresses a meaningful problem, a question which drives the investigation from start to finish.

Explanation:

You need a question to answer during the investigation to begin with. Hope this helped!

i believe that's the correct answer

hello, i am papaguy your answer is ready.

answer: the pronoun that is used in the given subject above is the word "himself" which refers to the noun or antecedent "maestro". the pronoun is an example of an intensive pronoun. intensive pronouns are used to add emphasis to the subject of the sentence and it uses reflexive pronouns such as myself, yourself, himself, herself, themselves and ourselves. 

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your pal papaguy