Help again please

When people are asked to recall a list of words they had earlier memorized, they often substitute synonyms for some of the words on the original list. this best illustrates the impact of:

Correct my question my english is not good: “what the effect and the effectiveness of strength exercise in breast cancer medication related to lymphedema? ”

What is the best definition of the underlined word as it is used in the sentence? a statement of wit or amusement an expression of disapproval or condemnation a sentiment of indifference or apathy an exclamation of profound admiration or esteem