What’s the answer just tell me the letter

Correct my question my english is not good: “what the effect and the effectiveness of strength exercise in breast cancer medication related to lymphedema? ”

Can someone me answer this english question

What is the best definition of detonation a.) the meaning of the word in a different language b.)the dictionary meaning of the word c.) the additional meaning that comes from the feeling one gets from a word d.) the meaning of irony