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Một thuốc A (IV) ở ba liều 100, 200 và 400mg cho 12 người tình nguyện khỏe mạnh, mỗi liều cách nhau một tuần. Nồng độ thuốc trong máu được xác định theo thời gian AUC0 (100mg) =12 mg. H/L AUC0 (200 mg)=25 mg. H/L AUC0(400 mg)=49 mg. H/L Trên cùng nhóm người này cho dùng chế phẩm A (PO) với liều 100mg, AUC0(100mg)=7,2mg. H/L 1. Sinh khả dụng tuyệt đối (F%) của chế phẩm A(PO)
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Một thuốc A (IV) ở ba liều 100, 200 và 400mg cho 12 người tình nguyện khỏe mạnh, mỗi liều cách nhau...
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