3. Even a gene mutation that is a point mutation, meaning it affects one nucleotide base, can still make a major change.
Sickle Cell Anemia is caused by a point mutation known as a
substitution. Complete the following example of a
substitution:
If the following is for normal hemoglobin:
Show what would occur if the first T (“thymine”) DNA base in
the portion shown above mutated to an A (“adenine”).
Sickle Cell Hemoglobin:
Portion of mutated hemoglobin DNA:
mRNA:
Amino
Acids: