Which statement regarding regulation of the citric acid cycle is false? Ca2+ is involved in citric acid cycle regulation in vertebrate muscle. Dysfunction of the citric acid cycle (e. g., due to mutations in enzymes of the cycle) is often associated with different types of cancer. As [NADH]/[NAD+] increases, flux through the cycle increases. In addition to regulation of the PDH complex, regulation of the citric acid cycle occurs by regulation of the enzymes that catalyze the strongly exergonic steps.