Explain the energetic benefits of making the enzyme active site complementary to the transition state rather than to the substrate conformation. Also explain how multiple weak interactions contribute to enzyme action. (In other words, how do these weak interactions between the enzyme and the transition state lower the activation energy?)

Explanation:

If the enzyme active site is complementary to the substrate conformation rather than to the transition state, it is unlikely that the reaction will proceed and release a product, because the enzyme-substrate complex will be tightly bound (ΔG will raise).

On the other hand, when the enzyme active site is complementary to the transition state, the substrate will not be tightly bound and will be more prone to be transformed into the product (ΔG will be lowered) and afterward, be released.

The weak interactions (non-covalent bonds) will stabilize the energy of the transition state and reduce its energy, thus lowering the activation energy). If the transition state is stable, it will form more easily and the reaction will be more likely to proceed.

1.consider the following balanced equation and answer parts a through. show calculations for each part.  

3 ag(s) + 4 hno3(aq) → 3 agno3(aq) + no(g) + 2 h2o(l)  

a. calculate the number of moles of agno3 produced by the reaction of 3 moles of ag with excess hno3. if the number to the left of the compound represents the number of moles of the compound which are present, then 3 moles of ag react with 4 moles hno3 to produce 3 moles agno3 (aq).

so the answer to a would be 3 moles.

b. calculate the number of moles of agno3 produced by the reaction of 108 grams of ag with excess hno3.  

i'm not sure how to plug in the grams of silver into an equation using moles to find how many moles are produced.

c. calculate the number of grams of agno3 produced by the reaction of 108 grams of ag with excess hno3  

d. calculate the number of moles of no produced as a byproduct of the reaction of 108 grams of ag with excess hno3.  

e. calculate the number of grams of no produced as a byproduct starting with 108 grams of ag and excess hno3.  

explanation:

i just learnt this recently but i need to look through my notes again