Consider these statements regarding the body's inability to convert fat to carbohydrates.
Select each statement that is true.

1. Acetoacetate is a normal, major energy source for the brain, heart muscle, and renal cortex.
2. Acetyl CoA that is produced from the oxidation of fatty acids and enters the citric acid cycle is used in the de novo synthesis of pyruvate.
3. The acetyl CoA that is produced from the oxidation of fatty acids enters the citric acid cycle but does not lead to a net gain of oxaloacetate.
4. The decarboxylation steps of the citric acid cycle prevent the net synthesis of glucose precursors from acetyl CoA in animal tissues.
5. Metabolism of odd-chain fatty acids yields propionyl CoA, which is converted to succinyl CoA and can enter the citric acid cycle.

The acetyl CoA that is produced from the oxidation of fatty acids enters the citric acid cycle but does not lead to a net gain of oxaloacetate is the main reason for body's inability to convert fat to carbohydrates.

Explanation:

The food we consume essentially consists of three types of nutrients:

Fats , Carbohydrates , Proteins

Fats are required for body as they are essential fatty acids. By the food we eat different types of fats are produced which in turn produces various vitamins which are required by the body. These vitamins are only soluble in these fats.

Carbohydrates are one of the nutrients found in food. Most foods contain mixing of three nutrients. Carbohydrates are found majorly in the form of sugar, starch and fiber by many food industries.

The acetyl CoA that is produced from the oxidation of fatty acids enters the citric acid cycle but does not lead to a net gain of oxaloacetate is the main reason for body's inability to convert fat to carbohydrates.