-g Which three of the statements are true? The tendency of water to minimize its contact with nonpolar substances is called the hydrophobic effect. Hydrophobic molecules do not readily dissolve in water in part because water molecules involved in hydration cannot participate in normal hydrogen bonding with one another. Hydrophobic molecules are individually hydrated in water, increasing the entropy of the system. Nonpolar molecules are capable of forming micelles. Amphipathic (amphiphilic) lipids are the structural basis of biological bilayer membranes.