A protein that no longer functions because its shape has changed (e. g., as a result of heating) has been .

denatured

Explanation:

To denature a proteins means to subject the protein to a condition that makes the protein to stop functioning as usual. This is usually due to a permanent change in the structure or shape of the protein. A protein may be denatured by change in pH, heat of binding of other molecules to the protein molecule.

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