Sickle-cell anemia is associated with a mutation in the gene encoding the beta subunit of hemoglobin that results in a change from glutamic acid to valine at position 6. All other amino acids are identical to a normal hemoglobin molecule.

Substitution of base A to T  is causing non conservative missense mutation leading to valine instaed of glutamic acid. No frame shift.

Explanation:

Base substitution in DNA leads to diffenet mRNA code which leads to incoporation of Valine instead of glutamic acid during translation. As Glutamic acid was polar whereas valine is nonpolar therefore folding of polypeptide chain will be affected.

Substitution only causes change in code at a particular location and there is no frame shift therefore all other amino acids will remain same.

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