What reaction conditions most effectively convert a carboxylic acid to a methyl ester

The convenient and efficient sonochemical method for methyl esterification of carboxylic acids reaction conditions are ;

• catalyzation by polymer-supported triphenylphosphine (0.1 eq. PS-PPh3)

• in the presence of 2,4,6-trichloro-1,3,5-triazine (1.0 eq. TCT) and Na2CO3 (2.0 eq. )

• Temperature 50°C for 10 - 30 mins

Explanation:

Methyl esters of various carboxylic acids bearing reactive hydroxyl groups as well as acid- or base-labile functionalities could be rapidly prepared within short times in good to excellent yields in high purities without column chromatography.

in the given question, the partial pressure is calculated by using the ideal gas equation, that is, pv = nrt

here, p is pressure, v is volume = 25 l, n is number of moles = 0.0104 moles, r is gas constant = -0.0821 l.atm / mol.k

t is temperature = 273 k

p = nrt / v

p = (0.0104 mol × 0.0821 l.atm / mol.k × 273 k) / 25 l

= 0.0093 atm