Which of the following statements concerning the process of spontaneous folding of proteins is false?

a) it may be an essentially random process.
b) it may be defective in some human diseases.
c) it may involve a gradually decreasing range of conformational species.
d) it may involve initial formation of a highly compact state.
e) it may involve initial formation of local secondary structure.

(A) It may be an essentially random process.

Explanation:

The natural folding process of protein can be defective in several human infections and it usually comprises the initial generation of extremely compact state. It may also involve the systematical reduction in the range of conformational species and the initial generation of local structure. Therefore, the only false statement is option (A).

option A= It may be an essentially random process.

Explanation:

The most important driving force behind PROTEIN FOLDING is the HYDROPHOBIC FORCE. Protein Folding is when proteins are folded into their biochemically functional three-dimensional forms.

Protein folding occurs in the cellular compartment which is known as the endoplasmic reticulum. Protein Folding has four stages; (1).primary protein Folding stage,(2). secondary protein Folding stage, (3). tertiary protein Folding stage and quarternary protein Folding stage.

(1). PRIMARY PROTEIN FOLDING STAGE: In here we have a sequence of amino acids held together by peptide bonds.

(2). SECONDARY PROTEIN FOLDING STAGE: this is the stage where protein starts folding, we have the alpha helix structure and the beta pleated sheet.

(3). TERTIARY PROTEIN FOLDING STAGE: in this stage the protein is being folded into its precise 3D structure

(4). QUARTERNARY PROTEIN FOLDING STAGE: in this stage a peptide bond to other peptides, for instance in haemoglobin.

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