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Chemistry, 11.09.2019 00:30 jdiddy25

The nazarov cyclization is a versatile method for making five-membered rings, a common feature in many natural products. this process has been used successfully in the preparation of many complex structures with a wide variety of biological activities, including antibiotic and anticancer properties (org. lett. 2003, 5, 4931–4934). the key step of the nazarov cyclization involves a lewis acid, such as alcl3. in the first step of the mechanism, compound 1 interacts with alcl3 to form a lewis acid-lewis base complex. determine the site within compound 1 that interacts most strongly with the lewis acid and justify your choice by exploring the resonance structures of the resulting complex:

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