Enzymes catalyze reaction by stabilizing the if the enzyme binds to the substrate too well, the activation energy for the catalyzed reaction thus, the enzyme binds best to the and the activation energy

Transition state, decreases, substrates & gets decreased.

Explanation:

Most of the chemical reactions are slow because of the transition state barriers. It requires a lot of energy to cross the transition state barriers. So enzymes provide an alternate pathway for carrying out the reaction by stabilizing the transition state. When enzymes interact with the substrates with the help of functional groups present in their active sites it results in the lowering of activation energy because the transition state gets stabilized with the help of enzyme.

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