Beadle and Tatum used Neurospora to identify mutants affecting various biosynthetic pathways. Their research led them to develop the one gene, one enzyme hypothesis. We now know this hypothesis is too narrow in its description of genes. In what way(s) was their hypothesis is too narrow? (Check all that apply)

A. Some genes make RNAs that are not translated.
B. Some genes make RNAs that are not translated.
C. Many proteins in the cell are not enzymes.
D. Many proteins in the cell are not enzymes.
E. They were unable to isolate all of the enzymes involved in methionine biosynthesis.
F. They were unable to isolate all of the enzymes involved in methionine biosynthesis.
G. Many proteins are composed of two or more different polypeptides; so more than one gene is involved in making the functional protein.