Rheumatoid arthritis is a potentially debilitating disease that

rheumatoid arthritis (ra) is a chronic, inflammatory synovitis-based systemic disease of unknown etiology. it is characterized by multiple joints of the hand and foot joints, symmetry, invasive joint inflammation, often accompanied by extra-articular involvement and serum rheumatoid factor positive, which can lead to joint deformity and loss of function.

matrix metalloproteinase-3 (mmp-3) also known as stromelysin-1 and transin (ec 3.4.24.17) cleaves a number of substrates including cartilage proteoglycan, collagen types ii, iii, iv, v and ix, fibronectin, laminin, and can activate mmp 1. mmp-3 is secreted as 57 and 59 kda proenzymes and can be activated in vitro by organomercurials (e.g., 4 aminophenylmercuric acetate, apma) and in vivo by proteases via intermediate forms to a 45 kda active mmp 3 enzyme. further autolysis to a 28 kda form can also occur. mmp-3 is thought to play an important role in pathophysiological degradation processes associated with conditions such as rheumatoid arthritis and cancer cell invasion.

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a. the production of carbon dioxide through the process of photosynthesis

the oxygenated blood then leaves the lungs through pulmonary veins, which return it to the left heart, completing the pulmonary cycle. this blood then enters the left atrium, which pumps it through the mitral valve into the left ventricle. from the left ventricle, the blood passes through the aortic valve to the aorta.

deoxygenated blood leaves through the right ventricle through the pulmonary artery. from the right atrium, the blood is pumped through the tricuspid valve (or right atrioventricular valve), into the right ventricle.