Why do plant cell possess large size vacuole?

Humans are believed to have evolved in coastal regions in east africa. the region had an abundant supply of fish for early humanoids to eat. when scientists analyze the fads gene they see an interesting pattern. people whose families have lived in this area of east africa for generation show a high level of diversity in alleles for the fads gene. conversely, people whose families had migrated inland a moderate distance from sources of fish showed a much lower diversity for fads gene alleles. additionally, the fads alleles found in people whose family has lived inland for generation are almost all gene alleles which produce fads proteins with a high level of function and activity. how do anthropologists explain this?

Fossils of ancestors of the modern horses show a small 4-toed almost dog-like browsing animal named eohippus over time the horses got larger lost toes and changed to a grazing diet what is the best explanation of why this change occurred

The result of saul's disobedience was1. samuel became the next king in place of saul.2. agag, the king of the amalekites broke free and killed saul.3. the lord rejected saul from being king.4. he was sent to live with jesse in bethlehem.plz plz