Anxiety disorders are a leading cause of dalys among:

Females, ages 15-19

Anxiety disorders are a leading cause of disability adjusted life years (DALYs) among females between the ages of 15-19. Anxiety disorders are  groups of mental disorders distinguished by significant feelings of anxiety and fear. These feelings may cause physical symptoms, such as a fast heart rate and shakiness. There are a number of anxiety disorders. They include generalized anxiety disorder, specific phobia, social anxiety disorder, separation anxiety disorder, agoraphobia and panic disorder.

the solute can move "downhill," from regions of higher to lower concentration, relying on the specificity of the protein carrier to pass through the membrane. this process is called passive transport or facilitated diffusion, and does not require energy.