Influence of exogenous and endogenous tissue-type plasminogen activator on the lysability of clots in a plasma milieu in vitro c. zamarron, h. r. lijnen, d. collen

The influence of the fast-acting inhibitor of t-PA on clot lysability by endogenous or exogenous t-PA was investigated by immersing clots prepared from normal or inhibitor-rich plasma (endogenous inhibitor) in normal or inhibitor-rich plasma (exogenous inhibitor). Exogenous t-PA inhibitor efficiently neutralizes clot lysis by both exogenous and endogenous t-PA. Endogenous t-PA inhibitor, however, efficiently neuralizes endogenous t-PA but has little influence on clot lysis by exogenous t-PA. These findings indicate that t-PA inhibitor is not concentrated into a clot and that t-PA inhibitor in plasma efficiently neutralizes t-PA incorporated in a clot.

α2-Antiplasmin depleted plasma clots were more susceptible to lysis by both endogenous and exogenous t-PA than normal clots. Removal of α2-antiplasmin from the surrounding plasma resulted in even shorter lysis times.

It is concluded that not only the concentrations of t-PA and of t-PA inhibitor play a role in the regulation of thrombolysis, but also their distribution between the clot and the surrounding plasma. In addition, α2-antiplasmin counteracts clot lysis significantly.

the national environmental policy act (nepa) is a united states environmental law that promotes the enhancement of the environment and established the president's council on environmental quality (ceq). the law was enacted on january 1, 1970. to date, more than 100 nations around the world have enacted national environmental policies modeled after nepa.

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