Bcells interacting with t cells are stimulated to differentiate when

There are choices for this question namely:

A) B cells produce IgE antibodies
B) B cells release cytokines
C) cytotoxic T cells present the class II MHC molecule-antigen complex on their surface
D) helper T cells release cytokines

The correct answer is "helper T cells release cytokines". Cytokines are released by helper T cells when B cells attach to them via receptors. These T cells "help" these B cells to differentiate by secreting certain cytokines. When B cells differentiate, they are converted to plasma cells and able to secrete antibodies to the antigen presented to the T cells.