Which organs or tissues prefer to use ketone bodies such as acetoacetate as a fuel energy source instead of glucose?

I think the appropriate would be the heart muscles and the renal cortex. Ketone bodies are three water-soluble molecules (acetoacetate, beta-hydroxybutyrate, and their spontaneous break down product, acetone) that are produced by the liver from fatty acids during low food intake (fasting), carbohydrate restrictive diets, starvation, prolonged intense exercise, alcoholism among others. In some tissues acetoacetate and beta-hydroxybutyrate can be reconverted to acetyl-CoA to produce energy. The heart gets much of its energy from ketone bodies, although it also uses a lot of fatty acids. The brain gets its energy from ketone bodies when insufficient glucose is available, e.g. during fasting.

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