Which factor prevented the protein molecules from moving out of the cell?

Proteins are some of major biomolecules that are found in all cells. They are synthesised in an organelle called ribosomes by a process called translation where the Ribosomes attaches on the mRNA and the anticodons on the tRNA interprates the codons on the mRNA. The molecule size of proteins prevent them from moving out of the cell because the cell membrane is semi-permeable and allows only small molecules and other selected materials to pass through.