What makes the domain eukarya uniquely different than the other domains bacteria and archaea?

enzyme active site and substrate specificity

enzymes bind with chemical reactants called substrates. there may be one or more substrates for each type of enzyme, depending on the particular chemical reaction. in some reactions, a single-reactant substrate is broken down into multiple products

photosynthesis makes the glucose that is used in cellular respiration to make atp. the glucose is then turned back into carbon dioxide, which is used in photosynthesis. while water is broken down to form oxygen during photosynthesis, in cellular respiration oxygen is combined with hydrogen to form water.