The most important factor affecting the ph of plasma is the concentration of

The appropriate response is carbon dioxide. Since carbon dioxide responds with water to shape carbonic corrosive, an expansion in CO2 brings about an abatement in blood pH, bringing about hemoglobin proteins discharging their heap of oxygen. 
An excess of carbon dioxide in your blood can hurt your body's organs. Both of these issues—a low oxygen level and a high carbon dioxide level in the blood—can happen in the meantime. Maladies and conditions that influence your breathing can cause respiratory disappointment.