When comparing the genomes of prokaryotes verse eukaryotes, it can be accurately stated that

enzyme active site and substrate specificity

enzymes bind with chemical reactants called substrates. there may be one or more substrates for each type of enzyme, depending on the particular chemical reaction. in some reactions, a single-reactant substrate is broken down into multiple products

c. live where it’s cold and icy

the answer u all are looking for is 4000000000000000000000 million years.