An experimental drug has been added to a eukaryotic cell, and while the drug was designed to interfere with a membrane transport process, the investigators found that in cells treated with the drug the lysosomes quickly turned into inclusion bodies. None of the material directed to the lysosomes for removal was being digested in the lysosome, and remained intact inside the organelle. An analysis of lysosomal contents in drug-treated cells indicated that the full complement of lysosomal enzymes were present in the organelle. Required:
Assuming that the drug is targeting just one protein, what proteins is most likely the target?

Why did the federal government end its support of yucca mountain as a site for long-term storage of nuclear water

Injuries in the environment are a result of

Mr. j, age 42, is a construction worker in las vegas. he recently noticed that a mole on his face seemed to be getting larger and darker. at first he did not worry because he was in the sun a lot and assumed the change may have been caused by sunburn. after a month, not only was the mole larger and darker, but it appeared to be “bumpy.” his doctor diagnosed a malignant melanoma skin cancer following biopsy of the nevus. mr. j reports pain in his right shin that does not go away when he puts his feet up or sleeps. discussion questions 1. relate mr. j’s skin changes to the warning signs for malignant melanoma. (see malignant melanoma.) 2. discuss the normal progression of this malignancy. what is the significance of the bone pain that mr. j is experiencing? (see malignant melanoma.) 3. discuss the treatment available for this patient and the prognosis for recovery. (see malignant melanoma.)