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each of the 46 original chromosomes splits into two daughter chromosomes, so there are two sets of 46 daughter chromosomes that end up in each cell. human cells have 46 chromosomes. each chromosome consists of a pair of identical chromatids attached together by a structure called a centromere.

osteogenesis imperfecta (oi) refers to a congenital ailment of bones. in the condition, the bones become brittle or fragile. this ailment is a general result of the defect or mutations in the genes (colia1 or colia2). this mutation results in imperfect collagen formation either in quantity or quality wise.  

there are eight kinds of oi defects, and each kind varies with certain distinctions in symptoms. the usual symptoms include frequent bone fractures, loss of hearing in infants, protruding eyes, discoloration of the white in the eyes, respiratory issues, loosening of the joints, short stature, and other symptoms.