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Only mutations that involve chromosomal rearrangements can result in the fusion of two different genes, which could code for a chimeric protein such as the BCR-ABL protein. Simple point mutations--insertion, deletion, or replacement of a single nucleotide--do not result in the fusion of two different genes. Which type of chromosomal rearrangement accounts for the creation of the gene that encodes the BCR-ABL chimeric protein
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