Alkaptoneuria is a recessive genetic disorder found among North American populations at a frequency of about 1 in 500,000 births. How frequently would you expect this defect to be expressed among children of second cousin marriages

The correct answer is - 1/41,493

Explanation:

Let assume the frequency of the two possible same allele genotype (dominant and recessive) in an inbred population is p and q. Then the frequency of heterozygotes (H) is denoted as:

2pq + 2pqF.  ( where F is the inbreeding coefficient).

The frequency of the two different hoozygotes in inbred population can be calculated as:

p2 + pqF and q2 + pqF. (Where p and q are the allele frequency of the dominant and recessive phenotype.

Given: Frequency of Alkaptonuria (q 2) = 1:500, 000

=> q = 1/707

p = 706/707 ( Approx values)

solution:

Inbreeding coefficient (F) = 1/64

Therefore,

Frequency of Alkaptonuria in second cousins= q 2 + pqF

= 1/500, 000 + (706/707 x 1/707) x (1/64)

= 1/500, 000 + 1/45, 248

= 1/41,493 (approx)

i love you and i play fortnite add me rod0107

before, trains worked using the steam engine. thus, it uses heat so it is crucial to apply heat balance. the steam engine absorbs energy during the stage of boiling water. so, this is the endothermic reaction. when the steam is used to work the piston, it has to release this energy through running the train. the excess energy is released as an exhaust to the chimney. this is the exothermic process because it releases energy to the surroundings.