Which of the following molecules would not pass through the cell membrane easily?

Charged Ions & Large Polar Molecules

Explanation:

The cell membrane's main trait is its selective permeability, which means that it allows some substances to cross it easily, but not others. Small molecules that are nonpolar (have no charge) can cross the membrane easily through diffusion, but ions (charged molecules) and larger molecules typically cannot.

An ion is a molecule that is charged because it has lost or gained an electron. The cell membrane is made of a bilayer of phospholipids, with an inner and outer layer of charged, hydrophilic "heads" and a middle layer of fatty acid chains, which are hydrophobic, or uncharged. Charged ions cannot permeate the cell membrane for the same reason that oil and water don't mix: uncharged molecules repel charged molecules. Even the smallest of ions -- hydrogen ions -- are unable to permeate through the fatty acids that make up the membrane. If ions "want" to enter the cell due to a high concentration of that type of ion on one side of the cell, they can do so by entering through the protein channels that are embedded between the lipids.

Large uncharged molecules, such as glucose, also cannot easily permeate the cell membrane. Although they do sometimes manage to slip across the membrane through diffusion, the process is extremely slow due to the size of the molecules. In order for these molecules to cross the membrane at a normal rate of speed, they need to resort to ion channels and specific transporters, which require energy output from the cell.

the oldest known insects are believed to live around 400 millions ago as suggested by the fossil records.   some plants having woody stems also evolved during this time.

after the evolution of insects the first four legged species or the tetrapods evolved in shallow freshwater habitats from the intermediate species approximately 397 million years ago. the tetrapods went on conquering the land giving rise to amphibians, reptiles, mammals and birds.

the major split in tetrapods first occurred 340 million years ago branching off from amphibians.

363 million years ago when the carboniferous period began the insects started roaming on land and taking flights, following which the four limbed tetrapods adapted in the terrestrial habitat.