Are all genetic mutations harmful?

A single mutation can have a large effect, but in many cases, evolutionary change is based on the accumulation of many mutations with small effects. Mutational effects can be beneficial, harmful, or neutral, depending on their context or location. Most non-neutral mutations are deleterious.

the right side of the picture going down is:

polymerase

protein

transport vesicle

modified protein

the left side of the picture going down is:

dna helix

single-stranded rna

endoplasmic reticulum

ribosome

golgi apparatus

protein released from vesicle

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b. lithosphere, asthenosphere, mesosphere   is the answer most likely