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the principle of segregation describes how pairs of gene variants are separated into reproductive cells. from his data, mendel formulated the principle of segregation. we now know that the segregation of genes occurs during meiosis in eukaryotes, which is a process that produces reproductive cells called gametes.

the correct answer is option d.

an appositive is a noun, noun phrase or noun clause which follows another noun or noun phrase in order to describe it or name it another way. they are usually used between commas, brackets or dashes.

the example sentence with the correct use of commas is the following:

her uncle, the man over there in the red shirt, owns the hardware store in town.

osteogenesis imperfecta (oi) refers to a congenital ailment of bones. in the condition, the bones become brittle or fragile. this ailment is a general result of the defect or mutations in the genes (colia1 or colia2). this mutation results in imperfect collagen formation either in quantity or quality wise.  

there are eight kinds of oi defects, and each kind varies with certain distinctions in symptoms. the usual symptoms include frequent bone fractures, loss of hearing in infants, protruding eyes, discoloration of the white in the eyes, respiratory issues, loosening of the joints, short stature, and other symptoms.