What is the main body system affected from sickle cell anemia? Answer choices:

Digestive System

Nervous system

Circulatory System

Respiratory system

Muscular System

Skeletal System

Any and all major organs are affected by sickle cell disease. The liver, heart, kidneys, gallbladder, eyes, bones, and joints can suffer damage from the abnormal function of the sickle cells and their inability to flow through the small blood vessels correctly.

Explanation:

The main body system affected by sickle cell anemia is the Circulatory system.

Explanation:

According to John Hopkins Medicine (a reliable source), "Any and all major organs are affected by sickle cell disease. The liver, heart, kidneys, gallbladder, eyes, bones, and joints can suffer damage from the abnormal function of the sickle cells and their inability to flow through the small blood vessels correctly."

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