The best way to destroy harmful germs that may be present in meat is to:

The best way to destroy harmful germs that may be present in meat is to cook foods to the right temperature.
It is a known fact that various types of germs and bacteria are susceptible to high heat - which is why if you want to eliminate them from your food, you should either cook them, boil them, fry them, or something like that using a high temperature in order to kill the germs and bacteria.