The adrenal medulla secretes epinephrine during sympathetic stimulation. which of the following statements describes why epinephrine would increase the sympathetic response? the adrenal medulla secretes epinephrine during sympathetic stimulation. which of the following statements describes why epinephrine would increase the sympathetic response? epinephrine increases the action of pre- and postganglionic axons. epinephrine binds to a separate receptor than norepinephrine, which increases the sympathetic response. the same receptors that respond to norepinephrine also respond to epinephrine, increasing the action of both. epinephrine has no effect on sympathetic targets.