What can happen to enzymes if ph, temperature, or concentration changes?

Been sitting here trying to take this test and don't know this answer! place the events of a feedback mechanism associated with body temperature in the correct order. ·nerve cells send message from skin to the brain ·body returned to normal temperature around 98.6 degrees f ·temperatures regulation center in the brain sends out signals ·body temperature exceeds 98.6 degrees f ·sweat glands throughout the body activate to cool off skin surface it is a 1 through 5 question in biology!