When patients who are receiving glucocorticoid therapy (for example, with prednisone) need to stop taking it, the doctor will prescribe a series of doses of tapering size to gradually lower the dose rather than suddenly stop it. explain this dosage strategy in terms of the negative feedback control of cortisol secretion.

At the point when taking a patient off an exogenous wellspring of cortisol, the body needs time to up direct creation of corticotropin and adenocorticotropin. On the off chance that the patient is taken off too unexpectedly, the body does not have room schedule-wise to adjust and there won't be sufficient of the middle of the road hormones present to empower creation of enough cortisol to address the body's issues.