A certain mutation in the gene for hemoglobin results in the red blood cells becoming sticky, rigid, and irregularly shaped. These irregularly shaped red blood cells block the flow of blood
throughout the body. A single base mutation is responsible for these irregularly shaped blood
cells
Hemoglobin Gene Mutation
Normal gene
Mutated gene
TT
SAG
DNA
Mutation
CAC
mRNA
GU
GUC
Protein Normal
VDC
Mutated
protein
protein
Which of these mutations most likely results in the mutated hemoglobin gene?
Substitution
Duplication
Insertion
Deletion