In humans, nearly 80% of proteins are acetylated on their N-terminal residue, a modification known to be recognized by a specific E3 enzyme, which directs the ubiquitylation of the protein for rapid degradation. Does this mean that all of these proteins would be actively degraded at the same time

Yes

Explanation:

Yes this means that all of these proteins will be actively degraded and this is due to the high turnover rate which will ensure that their activity will be under tight control.

The acetylation of the N-terminal of the protein, with the Ubiquitylation of the protein by an E3 enzyme, helps in the maintenance of the homeostasis of protein activity.

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