Suppose virus A has a viral genome of 19,000 bp, and 10,000,000,000 viruses are replicated in an infected individual in a single day. Assume that a single mutation at a particular location in the virus A genome is needed for virus A to develop antiviral drug resistance to ledipasvir. The mutation can be a transition or transversion mutation. If RNA polymerase introduces an error in 1 of every 10,000 bases synthesized, how long will it take for virus A to overcome ledipasvir therapy and develop resistance? Round your answer up to a whole number of days.

1 day.

Explanation:

From the given information:

The rate of mutation induced by RNA polymerase is:

Since the genome comprise of 19000 bp;

To complete a single replication, the viral cycle induce:

However, in a single day; 10,000,000,000 viruses are reported to be replicated.

Hence, if a virus has 2 mutations; Then 10,000,000,000 virus will have:

SO, to round this up to whole number, it will take 1 day (s) to overcome the therapy.

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hope this you! : )

(i popped my answer into google translate so it may be a bit wonky)

the corpus luteum secretes estrogens and progesterone. the latter hormone causes changes in the uterus that make it more suitable for implantation of the fertilized ovum and the nourishment of the embryo. if the egg is not fertilized, the corpus luteum becomes inactive after 10–14 days, and menstruation occurs.

i hope this : )