The white blood cells in the lungs release protease. Suggest the function of this enzyme in the white blood cells in the lungs. ( Pls don't answer for points. Serious answers only )

Explanation:

Many proteases are involved in the inflammatory process of COPD and responsible for the destruction of elastin fibers in the lung parenchyma, therefore, identification of those enzymes and other inflammatory mediators as well as understanding their interactions are important for the development of anti-inflammatory treatments for this disease. Redundancy among protease functions and the multiple beneficial effects of MMPs at different sites make those classes of proteases a challenging task to use in the field. Despite of published evidences there are challenges to consider the complexity of proteases and their inhibitors networks. No single molecule could be proposed yet for wide use in clinical practice, therefore, there is a need of basic study to look into detail with modern tools of biochemistry and molecular biology. The current approach of targeting specific pathways/ or processes of these proteases, but only after detail evaluation and the mechanism of these targets are likely to be a safer and more practical approach. The invention of novel NE inhibitors with high potency and low toxicity are the requirement of present time as in the future it may be used for patient therapy. To find out the cause of destruction of lung tissue in patients, it would be worth to study the role of proteases and their imbalance between proteolytic and anti-proteolytic activities and related oxidative stress in great details. The clinical diagnosis of COPD cases could be strengthened by adopting translational bench-to-bedside approach applying proteases biochemistry to biological samples obtained from clinically diagnosed patients. The complexity of COPD will definitely require a multi-target therapeutic approach. Therefore, other targets beside proteases would be beneficial to consider in COPD.

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