Predict the most likely effect on cell division for a cell containing DNA with double-strand breaks. Justify your prediction.

it may lead to the arrest of the cell division cycle

Explanation:

The presence of DNA double-strand breaks (DBS) during cell division generally leads to the activation of cell cycle 'surveillance' checkpoint mechanisms. The surveillance mechanisms act to ensure the correct functioning of the cell during its division, controlling the order and fidelity of the events during the cell cycle. Some of the most important surveillance mechanisms include spindle assembly checkpoint, proper cell size, replication/integrity of the chromosomes, etc. If surveillance mechanisms detect a problem with the DNA (e.g., a DBS), they will lead to the arrest of the cell division cycle, and the cell will try to either complete DNA replication or repair its damaged DNA. When DNA damage is irreversible, surveillance mechanisms may trigger programmed cell death (apoptosis).

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