Consider a transmembrane protein with the topology on the right that has an internal signal sequence (helix 1). If you fuse a canonical ER signal sequence at the N-terminus of this protein, how would you expect the topology to change

Over the past 60 years, many amphibian species have experienced significant population declines and some species have become extinct. scientists suspected that local human activities such as the destruction of wetlands, regional pollution, and deforestation were the main reasons for these losses. however, research over the past 20 years reveals significant amphibian population declines in protected areas of the world, such as nature preserves and parks. these global declines suggest widespread problems including increased ultraviolet radiation, acid rain, and disease. in switzerland, for example, 14 of the 20 native amphibian species are threatened with extinction. chytridiomycosis is a fungal disease first identified in 1998 as a cause of massive amphibian deaths. in some severely impacted populations, a few individuals have survived, perhaps because of some natural resistance. if these resistant individuals continue to survive and prosper, new resistant populations might emerge. this would be an example of the founder effect artificial selection genetic drift natural selection sexual selection

Darrel conducted an experiment with the following procedure: fill two cups with ice water. place an uninflated balloon snuggly onto your left index finger. blow a little air into an identical balloon, and place it onto your right index finger. place both fingers into the cups of ice water. darrel noticed that his right finger felt warmer in the ice water than did his left finger. which of the following does the experiment show? a. air is a good radiator of heat. b. air is a good insulator of heat. c. air is a good conductor of heat. d. air is a good convector of heat.

The accompanying figure shows the percent of selected dna sequences that match between a chimpanzee and other primates. these data support the hypothesis that the figure shows the percentage of selected d n a sequences that match between the chimpanzee and other primates. the human has an almost 98 percent match, the gorilla has an almost 97 percent match, the orangutan has a 96 percent match, the gibbon has an almost 95 percent match, and the old world monkey has an almost 92 percent match. the accompanying figure shows the percent of selected dna sequences that match between a chimpanzee and other primates. these data support the hypothesis that the figure shows the percentage of selected d n a sequences that match between the chimpanzee and other primates. the human has an almost 98 percent match, the gorilla has an almost 97 percent match, the orangutan has a 96 percent match, the gibbon has an almost 95 percent match, and the old world monkey has an almost 92 percent match. chimpanzees and gibbons are the most closely related the chimpanzee's closest surviving relative is humans orangutans are the primates least closely related to chimpanzees old world monkeys and gibbons are the most closely related