You are a scientist studying DNA replication. You have the ability to introduce temperature-sensitive mutations into the bacteria that you are studying (temperature-sensitive mutations work normally at one temperature, but when you raise the temperature a little, the mutation exerts its effect. This allows you to grow colonies with mutations that would otherwise be lethal. The fact that these mutations are temperature sensitive has nothing to do with the problem, other than to make it accurate to how these would actually be done. In other words, don't worry about temperature-sensitivity at all. Just think about possible mutations). You want to mutate bacteria so that they will have the following phenotypes:
Very slow DNA replication
DNA replication with a lower mutation rate
A mutation where when the cell replicates its DNA, it dies.
Please come up with two different targets of mutation for each phenotype. Explain how each mutation would work, why you chose them, and any side effects there would be.