If a mouse is given a dose of radiation sufficient to destroy its immune system, then injected with purified hematopoietic stem cells, what should happen?
A )The mouse survives over 3 months and if successful transplantation
of their new HSCs rescues a second lethally irradiated recipient,
they can be considered to have received near pure HSC,
reconstituting their immune system.
B)The mouse's remaining immune cells will cause a graft versus host
immune reaction, targeting the new HSCs for destruction.
C)The new HSCs will over proliferate and the mouse will develop
leukemia.
D) the mouse dies as its immune system might attack the HSC.