The major mechanism of action of anandamide appears to be: Group of answer choices presynaptic facilitation. postsynaptic facilitation. presynaptic inhibition. postsynaptic inhibition.

presynaptic inhibition

Explanation:

Presynaptic inhibition is an inhibitory mechanism capable of modulating neurotransmitter release in the central nervous system (CNS), i.e., by suppressing the release of neurotransmitters from axon terminals. Endocannabinoids are neurotransmitters that bind to receptors in other cells, thereby indirectly affecting the activity of other neurotransmitters. Anandamide is a neurotransmitter derived from arachidonic acid -an omega-6 fatty acid-, whose effects are mediated by cannabinoid receptors in the CNS. This major endocannabinoid (anandamide) is thought to inhibit the release of the inhibitory neurotransmitter γ-aminobutyric acid (GABA).