The end replication problem is seen in

Unlike bacterial chromosomes, the chromosomes of eukaryotes are linear (rod-shaped), meaning that they have ends. The DNA at the very end of the chromosome cannot be fully copied in each round of replication, resulting in a slow, gradual shortening of the chromosome.

c

explanation:

small, big, or no change could occur in the phenotype. it could cause something as simple as a cats ears to curl backwards or something as frighting as death. it could also occur in the protien-coding area and have an effect on that but no effect on the amino acids. what has to occur is a changing in the hox gene or the control gene.